HS3 Conference


The Hippocampal Subfield Segmentation Summit (HS3) is an informal workshop for those who either develop or use subfield segmentation protocols and high resolution imaging of the hippocampus. The goal of the meeting is to get together the group of scientists who are interested in harmonizing across protocols and coming up with a unified subfield segmentation protocol. The purpose is also to discuss the merits and pitfalls of certain segmentation approaches and ultimate work towards the automation of segmentation procedures based on ground-truth segmentations in post-mortem samples.

HS3 meetings are open to the public and registration costs only go to cover meeting costs such as conference facility booking, coffee, refreshments, etc. There are typically discounted registration fees for students and postdocs and they are strongly encouraged to attend and participate.


Upcoming meeting:

Hippocampal Subfield Segmentation Summit 7 (HS3.7)

Date: Friday, July 14th (roughly 9am-5pm)
Location: London, England

More details to come, but in brief this will be a smaller meeting of the Boundary Working Group to continue efforts to develop an initial protocol for segmenting the hippocampal head.

This meeting will be made possible thanks to the financial support of the JPND 2016 call for “Working Groups for Harmonisation and Alignment in Brain Imaging Methods for Neurodegeneration” (see our project page here)


Past Meetings

Hippocampal Subfield Segmentation Summit 6 (HS3.6)

Date: April 2-3, 2017
Location: Douglas Mental Health University Institute, Montreal
Thanks to Mallar Chakravarty for hosting the meeting

This was a smaller meeting of the Boundary Working Group, during which members:

  • Provided an update on the harmonization effort for the hippocampal body
  • Worked towards developing an initial protocol for segmenting the hippocampal head



This meeting was made possible thanks to the financial support of the JPND 2016 call for “Working Groups for Harmonisation and Alignment in Brain Imaging Methods for Neurodegeneration” (see our project page here)

Hippocampal Subfield Segmentation Summit 5 (HS3.5)

Date: November 11, 2016
Location: Residence Inn San Diego Downtown
Thanks to Rosanna Olsen and Valerie Carr for hosting the meeting

Broadly, the aims of this meeting were to:

  • Provide an update on the harmonization effort from the Boundary Working Group
  • Engage the broader community about current and future directions
  • Share research findings during an afternoon research symposium

See the program for a full list of presentations.


Thanks to all who attended this productive meeting! It was extremely encouraging to learn about the progress made by members of the Boundary Working Group (BWG). Specifically, the BWG provided updates regarding development of a protocol to define: the outer boundaries of the hippocampal body (anterior/posterior, medial/lateral, inferior/superior), the inner boundaries of the hippocampal body (subiculum, CA 1, 2, 3, and dentate gyrus), and preliminary efforts to define subfields within the hippocampal head. We also learned about efforts from the Questionnaire Working Group to put these protocols into writing, which will first be disseminated to the BWG and then to the broader subfield community for feedback. We had a productive group discussion regarding the progress of these groups, and also heard an exciting series of research talks in the afternoon. We are enthusiastic about what we’ve been able to accomplish since our last meeting, and we aim to continue this pace of progress over the coming months!

Hippocampal Subfield Segmentation Summit 4 (HS3.4)

Dates: October 15 – 16, 2015
Location: Northwestern University, Chicago
Thanks to Lei Wang for hosting the meeting

We would like to thank all the participants of this exciting and successful meeting. This intense two-day retreat was a major step forward: we succeeded at developing a first draft of an harmonized protocol for subfield segmentation of the hippocampal body.

The meeting started with presentations of the recent progress from multiple working groups.Working_in_chicago

– Outer boundary group (presentation by David Berron). How should we use and/or adapt existing harmonized protocols for hippocampal volumetry (see the EADC-ADNI Harmonized Protocol project website) to our specific high-resolution images? How should we handle white matter? CSF pools? How should we deal with the specific issues related to partial voluming? Where is the most medial boundary of the hippocampus/subiculum?

– Histology working group. Laura Wisse presented preliminary data on the behalf of the histology working group (J. Augustinack, R. Insausti, K. Amunts and O. Kedo), showing segmentation of hippocampal subfields on high-resolution histology slices from three expert groups. The goal of the group was to provide ‘gold standard’ histology segmentations of the hippocampal body from multiple individuals.

– Body ranging rules. Where is the hippocampal body? On which slice does it starts? Where does it end? Ana Daugherty presented preliminary data on the reliability of previously-determined landmarks. For that purpose, 9 volunteers had assessed the boundaries of the hippocampal body on high-resolution MR images nicely provided by several groups of the harmonization project.

Following these presentations, we constituted small working groups to discuss and make decisions about specific boundaries: i) CA1-Subiculum, ii) CA1-2-3 and, iii) CA3-DG. After multiple discussions, decisions were made regarding each of these boundaries.

Next steps will be necessary to carefully check these rules; for example to check them more thoroughly with histology and to discuss their generalization across individuals, ie. considering hippocampi with variable (flat, round) shapes. Then, we will initiate a small-scale reliability attempt with expert raters.

Photo of the Retreat AttendeesChicago_retreat

Hippocampal Subfield Segmentation Summit 3 (HS3.3)

Dates: August 17 – 18, 2014
Location: University of California, Irvine
Hosted by the Center for Neurobiology of Learning and Memory.

Thank you to all those who attended HS3.3 at UC Irvine the past two days. The meeting was a great success! Not only did we lay out a procedure for our future progress (more on this in a later email) but we also made a lot of headway on deriving a proposal for a heuristic-based boundary for the CA1-subiculum (the area of most disagreement based on the quantitative comparison of 21 protocols). We are now working on putting this procedure in writing and our Questionnaire Working Group will disseminate it to the subfield community for feedback. We hope to continue this pace of progress and use a similar process for other boundaries in the hippocampus and medial temporal lobes. We will keep everyone updated on progress. We have also decided to push HS3.4 till next year until we have made sufficient progress on deriving a unified protocol proposal but we will be able to update the community during a symposium on hippocamaopl subfields at the Society for Neuroscience meeting in Washington, DC later this year.

HS3.3 Final Program

Photo of the HS3.3 Meeting Attendees

HS3.3 AttendeesBack row from left to right: John Pluta, Rosanna Olsen, Mallar Chakravarty, Helen Keefe, Naftali Raz, Allen Chang, Arne Ekstrom, Susanne Mueller, Mike Yassa, Paul Yushkevich, Valerie Carr, Karen LaRoque, Natalie De Shelter, Maria Montchal, Ana Daugherty, Zach Reagh. Front row (seated) from left to right: Geoff Kerchner, Craig Stark, Stephanie Leal, Robert Amaral.

Hippocampal Subfield Segmentation Summit 2 (HS3.2)

Society for Neuroscience Meeting, San Diego, CA
Satellite Meeting

When: Saturday, November 9, 2013 from 8:00 AM to 12:00 PM (PST)
Where: Residence Inn San Diego Downtown Gaslamp Quarter
356 6th Avenue, San Diego, CA 92101

The aims of this meeting were:
(1) Discuss the quantitative analyses of your segmentation submissions
(2) Identify one or two subfields demonstrating the most disagreement among segmenters
(3) As a group, address these disagreements and move towards a unified segmentation

Hippocampal Subfield Segmentation Summit 1 (HS3.1)

The first HS3 meeting (HS3.1) was held on June 21-22, 2013 at the University of California, Davis and was a great success!

Thank you to all who attended and made the summit a productive experience. Special thanks go to Cam Carter, the Director of the Center for Neuroscience at UC Davis, who generously funded the catering for the meeting.

Browse the program | Browse abstracts